Vacancies: 01
Education: BSc, MSc, BPharm, MPharm (Specialization in QA)
Experience: Having more than 3 years of Experience in Quality Assurance
Salary: Best in Industry
Mail your resume on : hr@espl.net.in
Job Location: Surat
Vacancies: 01
Education: BSc, MSc, BPharm, MPharm (Specialization in QA)
Experience: Having 1 to 2 years of Experience in Quality Assurance
Salary: Best in Industry
Mail your resume on : hr@espl.net.in
Job Location: Surat
Vacancies: 01
Education: BSc, MSc, (Microbiology)
Experience: Having 1 to 2 years of Experience in Quality Control Department will be an added advantage
Salary: Best in Industry
Mail your resume on : hr@espl.net.in
Job Location: Surat
Vacancies: 01
Education: BBA, MBA, B. Com, M. Com
Experience: Having 1 to 2 years of Experience in Marketing & Sales in Medical/Pharma Industry will be an added advantage
Salary: Best in Industry
Mail your resume on : hr@espl.net.in
Job Location: Ahmedabad
Vacancies: 01
Education: BSc, MSc, Any Graduates with Science Background
Experience: Having 1 to 2 years of Experience in Marketing & Sales in Medical/Pharma Industry will be an added advantage
Salary: Best in Industry
Mail your resume on : hr@espl.net.in
Job Location: Bangalore/ Delhi NCR
OBJECTIVE
The en-ABL e-registry is a post marketing multicenter registry with an objective to evaluate clinical safety and efficacy outcomes in patients treated with Abluminus® DES+ Drug Eluting stent.
DESIGN
Prospective, Multi-center, post-market multicenter registry for evaluation of ABLUMINUS® DES+ in real world scenario.
ENPOINTS
Primary End Points:
–Registry device oriented Major Adverse Cardiac Events (MACE) @ 1 year
–Cardiac death,
–Target Vessel Myocardial Infarction (TV-MI) or
–Target Lesion/Vessel Revascularization (TLR/TVR).
Secondary End Points:
–Stent Thrombosis (ST) defined as definite and probable stent thrombosis according to the ARC definition
–Registry device-related MACE will be assessed at 3 months , 9 months, 1 year, 2 years and 3 years.
Safety and efficacy outcomes in patients treated with Abluminus® DES+ Drug Eluting stent
Baseline characteristics
Demographics | |
---|---|
Age (years) | 57.52 ± 10.99 |
Male gender | 79.08 % |
Medical history/risk factors | |
Diabetes | 34.28 % |
Hypertension | 42.61 % |
Renal insufficiency | 1.93 % |
Prior MI | 12.50 % |
Prior PCI | 5.37 % |
Prior CABG | 1.98 % |
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|
Baseline Lesion Morphology |
No. of lesions=2764, No. of Device= 3048 | |
Number of lesions per patient | 1.19 |
Number of device per patient | 1.31 |
Extent of coronary artery disease | |
1 Lesion | 83.25 % |
2 Lesions | 14.82 % |
3 Lesions | 1.93 % |
Lesion Details | |
Diameter stenosis, mm | 87.02 ± 9.99 |
Long lesions (≥28 mm) | 53.62 % |
Small vessels (RVD ≤2.75 mm) | 55.28 % |
Device Details | |
Mean stent diameter (mm) | 2.94 ± 0.43 |
Mean stent length (mm) | 26.66 ± 8.78 |
Safety & Efficacy end-points at 1 year & 2 years
Safety & Efficacy in Complex Patients
Diabetes sub-group N=798 |
AMI sub-group N=893 |
Small vessel (≤ 2.75 mm) sub-group N=1168 |
Long Lesion (≥28mm) sub-group N=1354 |
Long Lesion (≥ 28mm) in small vessel (≤ 2.75 mm) sub-group N=684 |
|
---|---|---|---|---|---|
Underwent Follow-up∗,n(%) | 689 (86.34%) | 685 (76.71%) | 992 (84.93%) | 1091 (80.58%) | 575 (84.06%) |
MACE | 3.19 % | 2.91 % | 3.83 % | 3.66 % | 5.04 % |
Cardiac Death | 0.73 % | 0.88 % | 0.81 % | 0.92 % | 1.22 % |
TV-MI | 0.44 % | 1.02 % | 0.50 % | 0.46 % | 0.52 % |
TLR/TVR | 2.03 % | 1.02 % | 2.52 % | 2.29 % | 3.30 % |
ST | 0.87 % | 1.90 % | 0.91 % | 0.82 % | 1.04 % |
*Patients underwent 1 year follow-up till September 2017. Clinical Follow-up ongoing for remaining patients.
Patient History
59 year old Female
CAD
Diabetes Mellitus
ACS-STEMI <6-24 Hrs
Sever thrombotic Calcified lesion in Mid RCA
Type C lesion with 100% stenosis & TIMI grade 0
Treatment Summary
Successfully placed 3.5 x 40 mm Abluminus® DES+ stent at 16 ATM
Check angiography showed well deployed Mid RCA DES and TIMI grade 3 flow in the vessel
9 months angiographic follow-up Summary
Check angiography showed patency of the Mid RCA with TIMI grade 3 flow in the vessel
Patient History
54 year old Male
CAD
Diabetes Mellitus
Sever Thrombotic lesion with 100% stenosis in Mid LCX
Type C lesion with TIMI grade 0
Treatment Summary
Pre dilatation was performed with 2 ×15 mm balloon at 6-8 ATM
Successfully placed 2.5 x 32 mm Abluminus® DES+ stent at 16 ATM with post-dilation of 3 x 12 mm balloon at 16 ATM
Check angiography showed well deployed Mid LCX DES with TIMI grade 3 flow in the vessel
12 months angiographic follow-up Summary
Check angiography showed patency of the Mid LCX with TIMI grade 3 flow in the vessel
Patient History
56 year old Female
CAD
Diabetes Mellitus
Hypertension
Eccentric Sever Calcified lesion in Proximal LCX
Type B2 lesion with 99% stenosis & TIMI grade 2
Treatment Summary
Pre balloon dilatation was performed with 1.5×10 mm balloon at 10 ATM
Successfully placed 2.5 x 16 mm Abluminus® DES+ stent with post-dilation of 2.5 x 8 mm balloon at 16 ATM
Check angiography showed well deployed LCX DES and TIMI grade 3 flow in the vessel
9 months angiographic follow-up Summary
Check angiography showed patency of the Proximal LCX with TIMI grade 3 flow in the vessel
Patient History
53 year old Male
CAD
Previous MI
Diabetes Mellitus
Hypertension
Thrombotic lesion with 100% stenosis in Proximal RCA
Type B1 lesion with TIMI grade 0
Treatment Summary
Pre balloon dilatation was performed with 2.25×15 mm & 2.5×20 balloon at 14 ATM
Successfully placed 2.75 x 40 mm Abluminus® DES+ stent with post-dilation of 2.75x 40 mm balloon at 12 ATM
Check angiography showed well deployed Proximal RCA DES with TIMI grade 3 flow in the vessel
9 months angiographic follow-up Summary
Check angiography showed patency of the Proximal RCA with TIMI grade 3 flow in the vessel
Patient History
50 year old Male
CAD
Sever calcified Thrombotic lesion with 93% stenosis in Distal RCA
Type C lesion with TIMI grade 2
Sever Tortuosity
Treatment Summary
Pre balloon dilatation was performed with 2 ×15 mm & 2.5×10 balloon at 6-8 ATM
Successfully placed 3.5 x 24 mm Abluminus® DES+ stent at 12 ATM
Check angiography showed well deployed RCA DES with TIMI grade 3 flow in the vessel
9 months angiographic follow-up Summary
Check angiography showed patency of the Distal RCA with TIMI grade 3 flow in the vessel
Patient History
58 year old Male
CAD
Diabetes Mellitus
Smoker
ACS- STEMI
Eccentric lesion with 79% stenosis in Mid LAD
Type C lesion with TIMI grade 2
Treatment Summary
Pre balloon dilatation was performed with 2.5×40 balloon at 10 ATM
Successfully placed 2.5 x 40 mm Abluminus® DES+ stent at 12 ATM
Check angiography showed well deployed Mid LAD DES with TIMI grade 3 flow in the vessel
9 months angiographic follow-up Summary
Check angiography showed patency of the Mid LAD with TIMI grade 3 flow in the vessel
Director and Head of Cardiology
Life care Institute of Medical Sciences & Research &
Apollo Hospital International, Ahmedabad, Gujarat, India
Dr. Sameer Dani, MD, DM